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27th June 2013

Measurement of infliximab and anti-infliximab antibodies - analytical aspects and clinical implications

Commercial assays for monitoring Infliximab (IFX) and anti-drug antibodies (ADAb) are currently available.

Nick Unsworth, P. Irving, M.G.Ward, G. Richards

14th June 2013

The Mechanism of Allopurinol Induced TPMT Inhibition

Up to 1/5 of patients with wildtype thiopurine-S-methyltransferase (TPMT) activity prescribed azathioprine (AZA) or mercaptopurine (MP) demonstrate a skewed drug metabolism in which MP is preferentially methylated to yield methylmercaptopurine (MeMP)

Blaker PA, Arenas-Hernandez M, Smith MA, Shobowale-Bakre EA, Fairbanks L, Irving PM, Sanderson JD, Marinaki AM

12th June 2013

Pain, purpura and curly hairs

This review follows a patient presenting with symptoms of Vitamin C deficiency (scurvy) at St. Thomas' Accident and Emergency Department, outlining symptoms, diagnosis and successful treatment.

J D Fleming, B Martin, David Card and J E Mellerio

12th June 2013

Diabetes and gout: efficacy and safety of febuxostat and allopurinol.

Assess influences of demographics and co-morbidities of gout patients with or without diabetes on safety and efficacy of urate-lowering agents.

M. A. Becker, P. A. MacDonald, Professor Beverley Hunt, R. L. Jackson

4th June 2013

Genetic markers associated with toxcity to fluoropyrimidine therapy

Fluoropyrimidine drugs are extensively used for the treatment of solid cancers.

Loganayagam A,, Arenas-Hernandez M, Corrigan A, L Fairbanks, Lewis CM, Harper P, Maisey N, Ross P, Sanderson JD, Marinaki AM

10th May 2013

Dyslipidaemia: Failure to THRIVE: the end for niacin?

Statins are established as first-line therapies for the prevention of cardiovascular disease (CVD); however, they do not completely eliminate the future risk of CVD events.

Professor Anthony S. Wierzbicki

30th April 2013

The influence of gender and haemoglobin on TPMT activity

Pre-treatment measurement of red blood cell (RBC) thiopurine-S-methyltransferase (TPMT) activity is recommended to guide initial dosing of azathioprine (AZA) and mercaptopurine (MP).

P A Blaker, V C Kariyawasam, K V Patel, R M Goel, M G Ward, P M Irving, J D Sanderson

26th April 2013

The STOP the Bleeding Campaign.

According to the World Health Organization, traumatic injuries worldwide are responsible for over 5 million deaths annually.

Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Filipescu D, Professor Beverley Hunt, Komadina R, Maegele M, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Spahn DR

19th April 2013

Management of bleeding and coagulopathy following major trauma: an updated European guideline.

Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient.

Donat R Spahn, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Daniela Filipescu, Professor Beverley Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint

18th April 2013

Initial laboratory experience from the first UK centre offering anti-TNF-α drug and anti-drug antibody monitoring to aid personalised therapy

NICE guidance recommends the use of biologic drugs for the treatment of inflammatory disease in Rheumatology, Dermatology and Gastroenterology with restrictions.

N Unsworth, G Richards, P Irving, M Ward

Last updated: 23/09/2022

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