Vitamin K1 2,3- epoxide

Description: 
Liquid chromatography mass spectrometry (LC-MS/MS) for the determination of Vitamin K1
Clinical details: 
Vitamin K1 2,3-epoxide is the bi-product of vitamin K1 formed when vitamin K is used as a cofactor in protein modification. Normally vitamin K epoxide is rapidly recycled by the enzyme vitamin K epoxide reductase (VKOR) and is not normally detectable in blood. If the action of the VKOR enzyme is blocked by vitamin K antagonist type anticoagulants such as warfarin or rodenticide superwarfarins vitamin K1 2,3-epoxide accumulates and becomes detectable in the blood.
Related condition or disease: 
Vitamin K antagonist exposure
Reference range: 

<0.12 ug/L

Synonyms or keywords: 
Vitamin K epoxide
Units: 
ug/L
Department: 
Haemostasis and Thrombosis Department
Location: 
St Thomas' Hospital
Sample type and Volume required: 
SST
Call in advance: 
No
Turnaround time: 
10 days
Special sample instructions: 

Protect from light.

Criteria for acceptance / rejections of sample
Storage and transport: 
Sample must be protected from light, first class post
Contacts:
Nutristasis Unit at Blackfriars Hub
0204 591 0055
Nutristasis@synnovis.co.uk
Reference Chemistry, 1st Floor Blackfriars Hub
Friars Bridge Court
Blackfriars Road
London
SE1 8NZ

Laboratory opening times
Monday - Friday 09.00 - 17.00
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Laboratory: 
Nutristasis Unit at Blackfriars Hub

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Last updated: 17/03/2020