Measurement of AAT is indicated in the evaluation of the following: chronic obstructive airway disease (COPD); emphysema; neonatal and adult liver disease. AAT phenotyping will be added to samples where AAT concentrations are at the bottom of or below the reference range. Quantitative determination of α1‑antitrypsin in human serum and plasma on the Roche Cobas c702 systems using an immunoturbidimetric method.
Lower concentrations are found in early childhood and in old age. Increased concentrations are found in pregnancy and in individuals taking exogenous oestrogens. AAT is a slow acute phase reactant and serum concentrations rise 2-3 fold within days of trauma, acute infection or tissue necrosis. Persistent elevations are seen in chronic infections and malignant disease however, measurement of AAT in these circumstances is of little diagnostic value. Low concentrations may have diagnostic importance.