A1AT -Quantitative

Measurement of AAT is indicated in the evaluation of the following: chronic obstructive airway disease (COPD); emphysema; neonatal and adult liver disease. AAT phenotyping will be added to samples where AAT concentrations are at the bottom of or below the reference range. Quantitative determination of α1‑antitrypsin in human serum and plasma on the Roche Cobas c702 systems using an immunoturbidimetric method.
Clinical details: 
Lower concentrations are found in early childhood and in old age. Increased concentrations are found in pregnancy and in individuals taking exogenous oestrogens. AAT is a slow acute phase reactant and serum concentrations rise 2-3 fold within days of trauma, acute infection or tissue necrosis. Persistent elevations are seen in chronic infections and malignant disease however, measurement of AAT in these circumstances is of little diagnostic value. Low concentrations may have diagnostic importance.
Reference range: 

0.9 - 2.0 g/L. 

Synonyms or keywords: 
AAT, A1AT, AAQ, alpha-1-antitrypsin
Sample type and Volume required: 
Serum or plasma - 5mL SST (gold top) or EDTA (purple top) tube
Call in advance: 
Turnaround time: 
1 day
Storage and transport: 
No special requirement
Clinical Biochemistry - Blood Sciences at King's College Hospital
020 3299 4126
King's College Hospital
Bessemer Wing
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 09/10/2023