AFP (Alpha-foetoprotein)
Description:
Immunoassay for the quantitative determination of α1-foetoprotein in human serum.
Clinical details:
Alpha1-foetoprotein is a glycoprotein with a molecular mass of 70 kDa. It is an oncofoetal antigen, present in high concentration in foetal sera, that decreases to a very low concentration after birth. AFP can reappear in some cancer patients. This is due to the reactivation of certain genes as a result of the malignant transformation of cells.
Elevated AFP concentrations in maternal serum during pregnancy can indicate spina bifida, anencephalia, atresia of the oesophagus or multiple pregnancy.
Elevated AFP concentrations in maternal serum during pregnancy can indicate spina bifida, anencephalia, atresia of the oesophagus or multiple pregnancy.
Reference range:
See Chemistry Reference Ranges Document at Automated Chemistry Laboratory at Guy's and St Thomas'
Synonyms or keywords:
Oncofoetal antigen, tumour marker.
Units:
kIU/L
Department:
Sample type and Volume required:
Serum
Turnaround time:
1 day
Storage and transport:
Serum
Contacts:
Blood Sciences Department-Guy's And St Thomas' Hospital
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247
Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247
Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
Automated Chemistry Laboratory at Guy's and St Thomas' Clinical Advisory Service
Monday – Friday, 09:00-17:00 h: 07738897061
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
Last updated: 08/11/2021
