AFP (Alpha-foetoprotein)

Immunoassay for the quantitative determination of α1-foetoprotein in human serum.
Clinical details: 
Alpha1-foetoprotein is a glycoprotein with a molecular mass of 70 kDa. It is an oncofoetal antigen, present in high concentration in foetal sera, that decreases to a very low concentration after birth. AFP can reappear in some cancer patients. This is due to the reactivation of certain genes as a result of the malignant transformation of cells.
Elevated AFP concentrations in maternal serum during pregnancy can indicate spina bifida, anencephalia, atresia of the oesophagus or multiple pregnancy.
Reference range: 

See Chemistry Reference Ranges Document at Automated Chemistry Laboratory at Guy's and St Thomas'

Synonyms or keywords: 
Oncofoetal antigen, tumour marker.
Sample type and Volume required: 
Turnaround time: 
1 day
Storage and transport: 
Blood Sciences Department-Guy's And St Thomas' Hospital
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247

Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
Automated Chemistry Laboratory at Guy's and St Thomas' Clinical Advisory Service
Monday – Friday, 09:00-17:00 h: 07738897061
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 08/11/2021