Alpha-Feto Protein (AFP) measured by sandwich principle immunoassay using the Roche cobas 8000 - e801 analyser
Alpha1-foetoprotein is a glycoprotein with a molecular mass of 70 kDa. It is an oncofoetal antigen, present in high concentration in foetal sera, that decreases to a very low concentration after birth. AFP can reappear in some cancer patients. This is due to the reactivation of certain genes as a result of the malignant transformation of cells.
Elevated AFP concentrations in maternal serum during pregnancy can indicate spina bifida, anencephalia, atresia of the oesophagus or multiple pregnancy
Synonyms or keywords:
Oncofoetal antigen, tumour marker.