Alkaline Phosphatase Isoenzymes

When uncertainty persists in determining the origin of increased total alkaline phosphatase (ALP), isoenzyme studies are performed to determine which of the predominant isoenzyme, either bone, liver, intestine or if pregnant, the placenta, is causing the total increase.
Clinical details: 
Causes of a raised ALP can be physiological (e.g. growth/development, pregnancy, gender, transient hyperphosphatasaemia of infancy, macro-ALP complexes) or pathological (e.g. Paget's disease, extra-hepatic biliary tree obstruction, malignancy).
Reference range: 

Interpretative comments used. No ranges quoted.

Sample type and Volume required: 
Clotted (yellow SST tube) Serum.
Turnaround time: 
1 month
Reference Chemistry Laboratory at St Thomas'
0207 188 1264
4th floor, North Wing
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015