Allopurinol adherence monitoring (urine)

Allopurinol is a xanthine oxidase inhibitor used in the treatment of gout. Levels of allopurinol and oxypurinol in urine are useful for confirming adherence.
Clinical details: 
Monitoring adherence in patients treated for gout, HPRT deficiency or APRT deficiency. The test also measures urinary purine levels. In patients with purine overproduction due to HPRT deficiency, levels of insoluble xanthine in urine should be monitored, and if above the limit of solubility, the dose of allopurinol reduced to minimise the risk of a xanthine nephropathy. Allopurinol is also used in the treatment of APRT deficiency to prevent the formation of insoluble 2,8-dihydroxyadenine.
Reference range: 

Please contact thelaboratory to discuss

24h urine/ random urine
Sample type and Volume required: 
24 hr urine bottle/Universal container containing thymol
Turnaround time: 
3 weeks
Storage and transport: 
store in fridge (short term )or freezer, can thaw in 1st class post
Purine Research Laboratory at St Thomas'
020 7188 1266
St Thomas’ Hospital
North Wing - 4th Floor
Westminster Bridge Road
London SE1 7EH
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 15/12/2015