Anti-Müllerian Hormone (AMH)

AMH has a wide range of potential uses in reproductive medicine, particularly assessing ovarian reserve and predicting response to IVF treatment. Levels of AMH are known to be higher in women with PCOS.

In paediatrics, the measurement of AMH may be of value in the diagnosis of disorders of sex development (DSD). AMH may also be used as a tumour marker in the follow up of patients with granulosa cell tumours.

The laboratory launched the AMH Plus assay on 26/09/17. The AMH Plus assay is identical to the AMH assay with regards to analytical performance, formulation, production and standardisation.

The assay was launched in EU following the European Medicines Agency approval for dose determination of follitropin delta of Ferring (human recombinant follicle stimulating hormone). The AMH Plus assay has an additional intended use for of ‘the establishment of the individual daily dose of follitropin delta of Ferring’ in controlled ovarian stimulation in women undergoing an assisted reproductive technology program. The use of follitropin delta requires an individualised dosing algorithm based on the AMH Plus result and patient body weight.
Clinical details: 
AMH performs various physiological functions. AMH is secreted by the Sertoli cells in males and is responsible for Müllerian duct regression during embryonic development. AMH continues to be produced by the testes until puberty and then decreases slowly to residual post-puberty values. In females, serum AMH is low at birth, increasing to peak levels after puberty. Levels decrease progressively thereafter with age, becoming undetectable at menopause.
Reference range: 

See Chemistry Reference Ranges Document at Automated Chemistry Laboratory at Guy's and St Thomas'

Synonyms or keywords: 
Anti Müllerian Hormone, AMH
Sample type and Volume required: 
Serum preferred though lithium heparin plasma is also acceptable. Grossly haemolysed/lipaemic/icteric samples are not suitable.
Minimum sample volume 500 uL
Turnaround time: 
1 day
Storage and transport: 
For external samples, please transport frozen. Cell-free serum/plasma is stable for 3 days at 20-25 °C, 5 days at 2-8 °C and 6 months at -20 °C. For sample shipment, samples should be stored frozen. Repeated freezing and thawing of samples should be avoided (freeze only once).
Blood Sciences Department-Guy's And St Thomas' Hospital
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247

Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
Automated Chemistry Laboratory at Guy's and St Thomas' Clinical Advisory Service
Monday – Friday, 09:00-17:00 h: 07738897061
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

Print as a PDF

Last updated: 29/09/2022