Ovarian antibodies

Autoantibodies to ovarian tissue are mainly restricted to the theca cells. These are steroid producing cells and it has been demonstrated that the molecular target is the enzyme 17/alpha-hydroxylase (17/alpha-OH). Antibodies to 17/alpha-OH are found in patients with ovarian failure with autoimmune Addison’s disease (100%) and to a lesser extent in both autoimmune polyendocrine syndromes types 1 and 2 without ovarian failure. The incidence is reportedly very low in other autoimmune disorders such type1 diabetes and thyroid disease. The assay is an indirect immunofluorescence type using monkey ovary as a substrate.
Reference range: 


Negative / Positive
Sample type and Volume required: 
Clotted (Gold top vacutainer)
Turnaround time: 
21 working days
Special sample instructions: 

All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.

Storage and transport: 
Serum stored at 4°C should be sent by first class post
Time limit for extra tests: 
10 days
Diagnostic Immunology and Allergy Department at King's College Hospital
General Enquiry : 020 3299 8752 / 020 3299 1171
King's College Hospital
Bessemer Wing - 1st Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 23/05/2023