Apolipoprotein A-1

Apolipoprotein A-1 is often measured in conjunction with other lipid parameters (including Apo B-100) to assess cardiovascular risk and monitor response to therapy.
Clinical details: 
Apo A-1 comprises 65% of the Apo lipoprotein of HDL (high density lipoprotein), providing structural scaffold for its formation. It is also a co-factor for lecithin cholesterol acyl transferase (LCHAT), required for esterification of cholesterol to cholesteryl esters. HDL is involved in the reverse transport of cholesterol from peripheral tissues to the liver, from where it can be excreted. Hence Apo A-1 deficiency confers increased risk of coronary artery and peripheral vascular disease, even in the absence of other coronary risk factors.
Reference range: 

Hypoalphalipoproteinaemia occurs at ApoA-I < 0.6g/L Cardiovascular risk increases with ApoA-I < 1.2 g/L Hyperalpalipoproteinaemia occurs at ApoA-I > 1.7 g/L

Sample type and Volume required: 
Clotted (yellow SST tube). Serum.
Turnaround time: 
3 days
Special sample instructions: 

Seat the patient 5 minutes before sampling. Fasting sample preferred, but non-fasting acceptable. Patient should follow their normal diet for 3 weeks prior to sampling.

Reference Chemistry Laboratory at St Thomas'
020 7188 1264
4th floor, North Wing
St Thomas' Hospital
Westminster Bridge Road
London SE1 7EH
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015