Apolipoprotein A1

Apolipoprotein A-1 is the major protein constituent of high density lipoproteins (HDL) which is involved in reverse cholesterol transport.
Apo A-1 is often used as a biomarker for prediction of cardiovascular diseases and the ratio Apo B-100/ApoA-1 is a better predictor of the risk.
Clinical details: 
Apo A-1 comprises 65% of the apolipoprotein of HDL (high density lipoprotein), providing structural scaffold for its formation. It is also a co-factor for lecithin cholesterol acyl transferase (LCHAT), required for esterification of cholesterol to cholesteryl esters.
HDL is involved in the reverse transport of cholesterol from peripheral tissues to the liver, from where it can be excreted. Hence Apo A-1 deficiency confers increased risk of coronary artery and peripheral vascular disease, even in the absence of other coronary risk factors.
Reference range: 

See Chemistry Reference Ranges Document at Automated Chemistry Laboratory at Guy's and St Thomas'

Synonyms or keywords: 
Apo A, Apolipoprotein A
Sample type and Volume required: 
Turnaround time: 
3 days
Storage and transport: 
Blood Sciences Department-Guy's And St Thomas' Hospital
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247

Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
Automated Chemistry Laboratory at Guy's and St Thomas' Clinical Advisory Service
Monday – Friday, 09:00-17:00 h: 07738897061
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For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 08/11/2021