Apolipoprotein E Genotype

This test is not currently included in the laboratory's UKAS scope of accreditation to ISO15189:2012
Clinical details: 
Common genotype - ApoE3/E3
CVD risk increases by about 10% with each apoE4 allele
ApoE2/E2 is associated with remnant hyperlipidaemia
ApoE2/E4 and apoE4/E4 are associated with increased remnant lipoproteins

The assay is specific for the 3 genotypes. Other rarer ApoE mutations associated with hypertriglyceridaemia e.g. ApoELeiden are not detected.

Reference range: 

Not applicable




Sample type and Volume required: 
5 mL EDTA (purple top) whole blood, non fasting
Turnaround time: 
Batch dependent 4-8 weeks
Storage and transport: 
EDTA whole bloood - refrigerated. Do not freeze. Dispatch within 24 hrs and not more than 3 days. Transport at room temperature
Blood Sciences Department-Guy's And St Thomas' Hospital
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Contact: 020 7188 9247

Guy's Hospital
Southwark Wing - 4th Floor
Great Maze Pond
London SE1 9RT
Contact: 020 7188 4781
Automated Chemistry Laboratory at Guy's and St Thomas' Clinical Advisory Service
Monday – Friday, 09:00-17:00 h: 07738897061
Out of hours, weekends & bank holidays: find details on Rotawatch on Trust intranet GTi, or contact via GSTT switchboard.
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

Print as a PDF

Last updated: 29/12/2022