Interphase FISH Analysis for Translocations in Lymphomas

Fluorescent in situ hybridisation analysis is recommended for the detection of translocations involving the BCL2, CCND1 (cyclin D1/BCL1), MYC, BCL6, ALK1 and MALT1 loci, detected in lymphomas. It has been demonstrated as invaluable for the diagnosis of lymphomas especially in small samples such as core biopsies and FNAs. This can be carried out in paraffin processed tissue and in conjunction with conventional immunohistochemical staining for these three proteins.
Sample type and Volume required: 
Formalin fixed paraffin processed tissue which *ideally* has not been decalcified in acid.
Turnaround time: 
1 – 2 weeks
Storage and transport: 
First class post within 4 days (temperature not to exceed 30°C during transport)
Cellular Pathology at Guy's And St Thomas' Hospital
Histology: 0207 188 7188 extension 54611 , Cytology: 0207 188 2915, Oral Pathology: 0207 188 4367
Histopathology & Cytopathology Laboratories
Cellular Pathology
St Thomas' Hospital
North Wing - 2nd Floor
Westminster Bridge Road
London SE1 7EH

Head and Neck/Oral Pathology Laboratory
4th Floor, Tower Wing
Guy's Hospital
Great Maze Pond
London SE1 9RT

For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015