Sulpiride by LC-MS/MS
Clinical details: 
Sulpiride (Dolmatil, Sanofi-Synthelabo) is a substituted benzamide that is used as an antipsychotic and also as an antidepressant/anxiolytic in some countries. Sulpiride is slowly and incompletely absorbed after oral administration and extensively metabolised (about 20 % of an oral dose is excreted in the urine as unchanged drug). The plasma half-life of sulpiride is 6-8 h. Antipsychotic effects occur at daily oral doses of 400-1800 mg with a maximum reported daily dose of 3600 mg. Antidepressant effects generally occur at lower daily doses (50-300 mg). Sulpiride assay is sometimes useful in assessing adherence and in the diagnosis of acute poisoning. Steady-state plasma sulpiride concentrations in the range 270-780 μg/L have been reported in patients given 800 mg sulpiride/day, but plasma concentrations more than 500 μg/L are thought to be undesirable for optimal clinical response.
Sample type and Volume required: 
4 mL EDTA whole blood or 2 mL plasma or serum (pre-dose or ‘trough’ sample). Please avoid gel-separator tubes
Turnaround time: 
5 working days.
Storage and transport: 
Please refrigerate (if possible) if not sending immediately. Send by first class post.
Toxicology Department at King's Hospital
020 3299 5881
King's College Hospital
Bessemer Wing - 3rd Floor
Denmark Hill
London SE5 9RS
For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 03/10/2022