King's College Hospital Analytical Equipment Upgrade

Friday, 24 January, 2020

The Blood Sciences Laboratory (Biochemistry) at the Princess Royal University Hospital is undergoing an analytical equipment upgrade. The previous Roche analysers are being replaced by new Roche equipment.

From the following date the assays listed below will be run on the new Roche equipment with the corresponding reference ranges:

28th January 2020

Assay Age   Previous Range New Range
Male Female Male Female
Alanine Transaminase All IU/L 5-55 No change
Albumin All g/L 35-50 No change
Alkaline Phosphatase 0-1y IU/L 126-524 No change
1-3 IU/L 129-291 No change
3-6 IU/L 134-346 No change
6-9 IU/L 156-386 No change
9-11 IU/L 120-488 116-515 No change
11-13 IU/L 178-455 93-386 No change
13-15 IU/L 116-483 62-209 No change
15-18 IU/L 58-237 45-130 No change
19+ IU/L 30-130 No change
Alpha-1-antitrypsin All g/L 0.9-2.0 No change
Alpha-Feto Protein All kIU/L < 7 < 6
Ammonia All µmol/L 12-50 No Change
Amylase All IU/L <100 No Change
Angiotensin Converting Enzyme All IU/L 8-52 No Change
Aspartate Transaminase 0-2y IU/L 10.0-77.0 No change
3-6 IU/L 8.0-43.0 No change
7-13 IU/L 7.0-36.0 No change
14-18 IU/L 3.0-35.0 No change
19+ IU/L 5.0-38.0 No change
HCG All IU/L 0-5 0-2 ≤ 1 Non-pregnant pre-menopausal
≤ 7 Post-menopause
Bicarbonate All mmol/L 22-30 22-29
Bile Acids All µmol/L <14 No Change
C-Reactive Protein All mg/L <5 No Change
C3 All g/L 0.70-1.65 No Change
C4 All g/L 0.16-0.54 No Change
CA-125 All kIU/L <35 No Change
CA-153 All kIU/L 0-28 No Change
CA-199 All kIU/L 0-37 No Change
Adjusted Calcium 0-2m mmol/L 1.70-2.90 No change
2m-1y 2.20-2.90 No change
1-16y 2.20-2.70 No change
16+ 2.15-2.60 No change
Carbamazepine All mg/L 4-12 No change
Carcino-Embryonic Antigen 20-39y µg/L 0.1-5.0 0-3.4 (Smokers 0-5.5)
40+   0-6.1 (Smokers 0-7.0)
Chloride All mmol/L 90-110 No change
Cholesterol All mmol/L 1.0-5.0 No change
Conjugated Bilirubin All µmol/L 0-4 No change
Cortisol All nmol/L 130-580 133-537 (06:00-10:00)
68-327 (16:00-20:00)
Creatine Kinase All IU/L <150 No change
Creatinine All µmol/L 45-120 No change
CSF Glucose All nmol/L None No change
CSF Protein All g/L 0.25-0.45 No change
CSF Lactate All mmol/L 1.00-2.00 No change
Digoxin All µg/L 1.1-2.0 No change
Ethanol All mg/L None No change
Follicle Stimulating Hormone All IU/L 1.8-10 2-11 Follicular
2-9 Luteal
>25 Post-menopause		 1.5-12.4 3.5-12.5 Follicular
4.7-21.5 Mid-cycle
1.7-7.7 Luteal
25.8-134.8 Post-menopause
Free Androgen Index All None 25.0-90.0 <6.0 35.0-92.6 No change
Free Thyroxine All pmol/L 10.3-24.5 12.0-22.0
Free Tri-iodothyronine All pmol/L 3.5-6.5 3.1-6.8
Gamma-glutamyl Transferase All IU/L 1-55 No Change
Gentamicin 0-4w mg/L <2.0 No Change
4w+ <1.0 No Change
Globulin All g/L 25-35 No Change
Glucose All mmol/L 3-11 No Change
HDL cholesterol All mmol/L >1 No Change
Immunoglobulin A 0-14d g/L 0.01-0.08 0.02-0.08 No Change
14d-6w 0.02-0.15 No Change
6w-2m 0.05-0.40 No Change
2-6m 0.10-0.50 No Change
6-9m 0.15-0.70   No Change
6-12m   0.20-0.70 No Change
9-12m 0.20-0.70   No Change
1-2y 0.30-1.20 No Change
2-3y 0.30-1.30 No Change
3-6 0.40-2.00 No Change
6-9 0.50-2.40 No Change
9-12 0.70-2.50 No Change
12-45 0.80-2.80 No Change
46+ 0.8-4.0 No Change
Immunoglobulin G 0-14d g/L 5.0-17.0 No Change
14d-6w 3.9-13.0 No Change
6w-2m 2.1-7.7 No Change
2-6m 2.4-8.8 No Change
6-9m   3.0-9.0 No Change
6-12m 3.0-10.9   No Change
9-12m   3.0-10.9 No Change
1-2y 3.1-13.8 No Change
2-3y 3.7-15.8 No Change
3-6 4.9-16.1 No Change
6-9 5.4-16.1   No Change
6-45   5.4-16.1 No Change
9-15 5.4-16.1   No Change
16+ 6.0-16.0   No Change
45+   6.0-16.0 No Change
Immunoglobulin M 0-14d g/L 0.05-0.20 No Change
14d-6w 0.08-0.40 No Change
6w-2m 0.15-0.70 No Change
2-6m 0.2-1.0 No Change
6-9m 0.4-1.6   No Change
9-12m 0.6-2.1   No Change
6m-3y   0.5-2.2 No Change
1-3y 0.5-2.20 No Change
3-6 0.5-2.0 No Change
6-9 0.5-1.8 0.4-1.6 No Change
9-12 0.5-1.8 No Change
12-45 0.5-1.9 No Change
46+ 0.5-2.0 No Change
Iron All µmol/L 14.0-30.0 No change
Lactate All mmol/L 0.6-2.0 No change
Lactate Dehydrogenase All IU/L 0-240 No change
LDL cholesterol All mmol/L 1.0-3.0 No change
Lithium All mmol/L 0.6-1.0 0.4-1.0
Luteinising Hormone All IU/L 1.5-9.3 1-12.5 Follicular
1-12 Luteal
>25 Post-menopause		 1.7-8.6 2.4-12.6 Follicular
14.0-95.6 Mid-cycle
1.0-11.4 Luteal
7.7-58.5 Post-menopause
Magnesium All mmol/L 0.7-1.0 No change
NT-proBNP All pg/mL <400 pg/mL Heart failure unlikely
400-2000 pm/mL Requires review in heart failure clinic within 6 weeks (request ROUTINE appointment on e-referral)
>2000 pm/mL Requires review in heart failure clinic within 2 weeks (request URGENT appointment on e-referral)		 No change
Oestradiol All pmol/L <170 70-500 Follicular
250-1350 Mid-cycle
100-800 Luteal
<170 Post-menopause		 41 - 159 45-854 Follicular
151-1461 Ovulatory
82-1251 Luteal
≤ 505 Post-menopause
Paracetamol All mg/L None No change
Parathyroid hormone All ng/L 10-70 15-65
Phenytoin All mg/L 10-20 No Change
Phosphate 0-4w mmol/L 0.87-2.33 0.97-2.58 No Change
4w-3m 0.97-2.20 0.97-2.42 No Change
3m-1y 0.97-2.23 0.81-2.26 No Change
1-2 0.81-2.07 0.97-2.10 No Change
2-13 0.97-1.94 0.81-1.94 No Change
13-16 0.97-1.74 0.97-1.81 No Change
16-18 0.97-1.68 0.97-1.55 No Change
19+ 0.80-1.40 No Change
Potassium All mmol/L 3.5-5.0 No Change
Progesterone All nmol/L None <8 Follicular
>30 Post-ovulation		 ≤ 0.47 0.18-2.84 Follicular
0.39-38.1 Ovulation phase
5.82-75.9 Luteal
≤ 0.40 Post-menopause
Prolactin All mIU/L 100-410 100-510 86-324 102-496
Prostate Specific Antigen 0-39y µg/L   0.0-1.4  
40-49   0.0-2.0  
0-49 <2.5 None No Change
50-59 <3.5 None 0.0-3.1 No Change
60-69 <4.5 None 0.0-4.1 No Change
70+ <5.5 None 0.0-4.4 No Change
Rheumatoid Factor All IU/mL 0-14 0-13
Salicylate All mg/L <350 No Change
Serum Ferritin All µg/L 20-300 30-400 13-150
Serum Folate All µg/L 3.0-13.0 3.0-20.0
SHBG <50y nmol/L   18.3-54.1 32.4-128.0
≥ 50y (or all) 10-62 40-140 20.6-76.7 27.1-128.0
Sodium All mmol/L 135-145 No Change
Testosterone 0-12y nmol/L   0-1.0  
12y+ (All) 10-30 0.5-2.6  
0-6m   0.4-13.9  
>6m (male)
0-49y (female)		   8.6-29.0
If under 18 y:
Please note, reference range applies to adults. Please interpret result in context of pubertal stage:
Pre-puberty: <0.4 nmol/L
Post-puberty: 8.6 – 29.0 nmol/L		 0.4-1.7
If under 18y:
Please note, reference range applies to adults. Please interpret result in context of pubertal stage:
Pre-puberty: <0.4 nmol/L
Post-puberty: 0.4 – 1.7 nmol/L
≥ 50y (females)   0.4-1.4
Theophylline All mg/L 10-20 No Change
Thyroid Stimulating Hormone All mIU/L 0.3-5.5 0.27-4.20
Total Bilirubin 0-10d µmol/L 3-200 No Change
11-14d 3-50 No Change
15d+ 3-20 No Change
Total Iron Binding Capacity All µmol/L 45-80 No Change
Total Protein All g/L 60-80 No Change
Triglyceride All mmol/L 0.5-2.0 No Change
Troponin T All ng/L 0-13 0-14
Urate All µmol/L 180-420 No Change
Urea All mmol/L 3.3-6.7 No Change
Valproate All mg/L 50-100 No Change
Vancomycin All mg/L 10.0-20.0 No Change
Vitamin B12 All ng/L 180-1100 197-771
Vitamin D All nmol/L Deficiency <30 nmol/L
Insufficiency 30 to 50 nmol/L
Therapeutic target >50 nmol/L		 Deficiency <25 nmol/L
Insufficiency 25 to 50 nmol/L
Therapeutic target >50 nmol/L

King's College Hospital Denmark Hill Site

The Blood Sciences Laboratory at King’s College Hospital, Denmark Hill is undergoing an analytical equipment upgrade. The previous Siemens analysers and track systems are being replaced by new Roche and Sysmex equipment. The upgrade is taking place over a number of months in a phased process whereby the Biochemistry platform will be the first to be replaced, followed by Haematology and Coagulation.

From the following dates the assays listed below will be run on the new Roche/Sysmex equipment with the corresponding reference ranges:

17th September 2019

Assay Age   Previous Range New Range
Male Female Male Female
Alanine Transaminase All IU/L 5-55 No change
Albumin All g/L 35-50 No change
Alkaline Phosphatase 0-1y IU/L 126-524 No change
1-3 IU/L 129-291 No change
3-6 IU/L 134-346 No change
6-9 IU/L 156-386 No change
9-11 IU/L 120-488 116-515 No change
11-13 IU/L 178-455 93-386 No change
13-15 IU/L 116-483 62-209 No change
15-18 IU/L 58-237 45-130 No change
19+ IU/L 30-130 No change
Alpha-Feto Protein All kIU/L < 7 < 6
Anti-Thyroglobulin Antibodies All U/mL < 60 < 115
Amikacin All mg/L < 5.0 No Change
Ammonia All µmol/L 12-50 No Change
Amylase All IU/L <100 No Change
Angiotensin Converting Enzyme All IU/L 8-52 No Change
Aspartate Transaminase 0-2y IU/L 10-77 No change
3-6 IU/L 8-43 No change
7-14 IU/L 7-36 No change
14-18 IU/L 3-35 No change
19+ IU/L 10-50 No change
HCG All IU/L <5 <2 ≤ 1 Non-pregnant pre-menopausal
≤ 7 Post-menopause
Bicarbonate All mmol/L 22-30 22-29
Bile Acids All µmol/L <14 No Change
C-Reactive Protein All mg/L <5 No Change
C3 All g/L 0.70-1.65 No Change
C4 All g/L 0.16-0.54 No Change
CA-125 All g/L <35 No Change
CA-125 All g/L <35 No Change
Caeruloplasmin 0-3m g/L 0.08-0.23 No change
3m+ g/L 0.20-0.45 No change
Adjusted Calcium All mmol/L 2.15-2.6 No change
Carbamazepine All mg/L 4-12 No change
Carcino-Embryonic Antigen 20-39y µg/L <5 0-3.4 (Smokers 0-5.5)
40+ <5 0-6.1 (Smokers 0-7.0)
Chloride All mmol/L 90-110 No change
Cholesterol All mmol/L 1.0-5.0 No change
Conjugated Bilirubin All µmol/L <4 No change
Cortisol All nmol/L 130-580 133-537 (06:00-10:00)
68-327 (16:00-20:00)
Creatine Kinase All IU/L <150 No change
Creatinine All µmol/L 45-120 No change
Cystatin C 3m mg/L <1.71 No change
3m-50y <1.00 No change
50+ <1.40 No change
CSF Glucose All nmol/L None No change
CSF Protein All g/L 0.25-0.45 No change
CSF Lactate All mmol/L 0.7-2.0 No change
Ciclosporin All µg/L None No change
Digoxin All µg/L 1.1-2.0 No change
Follicle Stimulating Hormone All IU/L 1.8-10 2-11 Follicular
2-9 Luteal
>25 Post-menopause		 1.5-12.4 3.5-12.5 Follicular
4.7-21.5 Mid-cycle
1.7-7.7 Luteal
25.8-134.8 Post-menopause
Free Androgen Index All None 25.0-90.0 <6.0 35.0-92.6 No change
Free Thyroxine All pmol/L 9-25 12-22
Free Tri-iodothyronine All pmol/L 3.5-6.5 3.1-6.8
Gamma-glutamyl Transferase All IU/L 1-55 No Change
Gentamicin 0-4w mg/L <2.0 No Change
4w+ <1.0 No Change
Globulin All g/L 25-35 No Change
Glucose All mmol/L None No Change
Haptoglobin All g/L 0.8-2.2 No Change
HDL cholesterol All mmol/L >1 No Change
Immunoglobulin A 0-14d g/L 0.01-0.08 No Change
14d-6w 0.02-0.15 No Change
6w-3m 0.05-0.40 No Change
3-6m 0.10-0.50 No Change
6-9m 0.15-0.70 No Change
9-12m 0.20-0.70 No Change
1-2y 0.30-1.20 No Change
2-3y 0.30-1.30 No Change
3-6 0.40-2.00 No Change
6-9 0.50-2.40 No Change
9-12 0.70-2.50 No Change
12-15 0.80-2.80 No Change
16+ 0.87-4.12 No Change
Immunoglobulin G 0-14d g/L 5.0-17.0 No Change
14d-6w 3.9-13.0 No Change
6w-3m 2.1-7.7 No Change
3-6m 2.4-8.8 No Change
6-9m 3.0-9.0 No Change
9-12m 3.0-10.9 No Change
1-2y 3.1-13.8 No Change
2-3y 3.7-15.8 No Change
3-6 4.9-16.1 No Change
6-15 5.4-16.1 No Change
16+ 6.34-18.11 No Change
Immunoglobulin M 0-14d g/L 0.05-0.20 No Change
14d-6w 0.08-0.40 No Change
6w-3m 0.15-0.70 No Change
3-6m 0.20-1.00 No Change
6-9m 0.40-1.60 No Change
9-12m 0.60-2.10 No Change
1-3y 0.50-2.20 No Change
3-6y 0.50-2.00 No Change
6-12 0.50-1.80 No Change
12-15 0.50-1.90 No Change
16+ 0.53-2.23 No Change
Iron All µmol/L 14.0-30.0 No change
Lactate All mmol/L 0.6-2.0 No change
Lactate Dehydrogenase All IU/L <240 No change
LDL cholesterol All mmol/L 1.0-3.0 No change
Levetiracetam All mg/L 6.0-20.0 No change
Lipase All IU/L 5-65 No change
Lithium All mmol/L 0.6-1.0 No change
Luteinising Hormone All IU/L 1.5-9.3 1-12.5 Follicular
1-12 Luteal
>25 Post-menopause		 1.7-8.6 2.4-12.6 Follicular
14.0-95.6 Mid-cycle
1.0-11.4 Luteal
7.7-58.5 Post-menopause
Magnesium All mmol/L 0.7-1.0 No change
Oestradiol All pmol/L <170 70-500 Follicular
250-1350 Mid-cycle
100-800 Luteal
<170 Post-menopause		 41 - 159 45-854 Follicular
151-1461 Ovulatory
82-1251 Luteal
≤ 505 Post-menopause
Paracetamol All mg/L None No change
Parathyroid hormone All ng/L 10-70 15-65
Phenobarbitone All mg/L 10-40 No Change
Phenytoin All mg/L 10-20 No Change
Phosphate 0-4w mmol/L 0.87-2.33 0.97-2.58 No Change
4w-3m 0.97-2.20 0.97-2.42 No Change
3m-1y 0.97-2.23 0.81-2.26 No Change
1-2 0.81-2.07 0.97-2.10 No Change
2-13 0.97-1.94 0.81-1.94 No Change
13-16 0.97-1.74 0.97-1.81 No Change
16-18 0.97-1.68 0.97-1.55 No Change
19+ 0.80-1.40 No Change
Potassium All mmol/L 3.5-5.0 No Change
Progesterone All nmol/L None <8 Follicular
>30 Post-ovulation		 ≤ 0.47 0.18-2.84 Follicular
0.39-38.1 Ovulation phase
5.82-75.9 Luteal
≤ 0.40 Post-menopause
Prolactin All mIU/L 100-410 100-510 86-324 102-496
Prostate Specific Antigen 0-39y µg/L   0.0-1.4  
40-49   0.0-2.0  
0-49 <2.5 None No Change
50-59 <3.5 None 0.0-3.1 No Change
60-69 <4.5 None 0.0-4.1 No Change
70+ <5.5 None 0.0-4.4 No Change
Red Cell Folate All µg/L 150-650 523-1257
Rheumatoid Factor All IU/mL <20 <14
Salicylate All mg/L <350 No Change
Serum Ferritin All µg/L 20-300 20-200 30-400 13-150
Serum Folate All µg/L 3.0-13.0 3.0-20.0
SHBG <50y nmol/L   18.3-54.1 32.4-128.0
≥ 50y (or all) 10-62 40-140 20.6-76.7 27.1-128.0
Sodium All mmol/L 135-145 No Change
Testosterone All nmol/L 10-30 0.5-2.6  
0-6m   0.4-13.9  
>6m (male)
0-49y (female)		   8.6-29.0
If under 18 y:
Please note, reference range applies to adults. Please interpret result in context of pubertal stage:
Pre-puberty: <0.4 nmol/L
Post-puberty: 8.6 – 29.0 nmol/L		 0.4-1.7
If under 18y:
Please note, reference range applies to adults. Please interpret result in context of pubertal stage:
Pre-puberty: <0.4 nmol/L
Post-puberty: 0.4 – 1.7 nmol/L
≥ 50y (females)   0.4-1.4
Theophylline All mg/L 10-20 No Change
Anti-Thyroid Peroxidase Antibodies All U/mL <60 <34
Thyroid Stimulating Hormone All mIU/L 0.3-5.5 0.27-4.20
Tobramycin (Trough) All mg/L <1.0 No Change
Total Bilirubin All µmol/L 3-20 No Change
Total Iron Binding Capacity All µmol/L 50-72 No Change
Total Protein All g/L 60-80 No Change
Triglyceride All mmol/L 0.5-2.0 No Change
Troponin All ng/L <16 (Troponin I) 0-14 (Troponin T)
Urate All µmol/L 100-400 No Change
Urea All mmol/L 3.3-6.7 No Change
Valproate All mg/L 50-100 No Change
Vancomycin All mg/L 10.0-20.0 No Change
Vitamin B12 All ng/L 180-1100 197-771
Vitamin D All nmol/L Deficiency <30 nmol/L
Insufficiency 30 to 50 nmol/L
Therapeutic target >50 nmol/L		 No Change