ALA is a test offered by the SAAS Porphyria Service in Reference Biochemistry at King’s College Hospital. Quantitative measurement of ALA is carried out using ion-exchange chromatography and spectrophotometry
ALA is a precursor in the haem synthesis pathway and is elevated in patients during an acute porphyria attack. Increases in ALA excretion can also be seen in patients with hereditary tyrosinaemia and lead toxicity. Urine ALA is analysed and reported with urine PBG.