Aldosterone/Renin
Description:
Renin and aldosterone assayed by chemiluminescent immunoassay using the Diasorin Liaison
Clinical details:
The renin-angiotensin-aldosterone axis plays a vital role in sodium homeostasis and maintenance of blood volume and pressure. Disorders of the renin-angiotensin-aldosterone axis can lead to major metabolic imbalances and disease. Renin, aldosterone and their ratio are the most frequently measured parameters used to assess renin-angiotensin-aldosterone axis integrity.
Assessment of the renin-angiotensin-aldosterone axis has assumed a much greater role in clinical practice, particularly in the evaluation of patients with hypertension.
In addition, the axis is often evaluated in patients with:
- Hypo or hyperkalaemia who may have hyperaldosteronism (or other forms of genuine or apparent mineralocorticoid excess) or hypoaldosteronism respectively.
- Adrenal insufficiency - to distinguish primary from secondary cause.
Assessment of the renin-angiotensin-aldosterone axis has assumed a much greater role in clinical practice, particularly in the evaluation of patients with hypertension.
In addition, the axis is often evaluated in patients with:
- Hypo or hyperkalaemia who may have hyperaldosteronism (or other forms of genuine or apparent mineralocorticoid excess) or hypoaldosteronism respectively.
- Adrenal insufficiency - to distinguish primary from secondary cause.
Reference range:
Renin (mU/L): Upright 5.4 - 60, Supine 5.4 - 30
Aldosterone (pmol/L): Upright 100 - 800, Supine 100 - 450
Aldo/Renin ratio: <80: Conn’s unlikely, >/=200: Conn’s likely, 80-200: Conn’s not excluded
Department:
Location:
Sample type and Volume required:
EDTA Plasma - Plasma must be separated from cells immediately after centrifugation with a minimum volume of 1ml aliquoted into an appropriate tube. Store at –20ºC until transport.
Call in advance:
No
Turnaround time:
Results within 7-10 working days
Storage and transport:
Must be sent frozen by courier.
Address specimens to: Department of Clinical Biochemistry, Bessemer Wing, King’s College Hospital, Denmark Hill, London SE5 9RS
Contacts:
For clinical advice or interpretation of results, please contact the laboratory in the first instance.
Last updated: 13/08/2023
