BCRABL Initial Screen
Description:
The BCR-ABL fusion gene is detected in 95% of CML cases, in 25-30% of adult ALL and 2-5% of childhood ALL .The BCRABL fusion transcript is the result of the reciprocal translocation between the long arms of chromosome 9 and chromosome 22 - [t(9;22)]. The breakpoint in the ABL-gene is generally 5’ of the exon a2. The major breakpoint region (M-bcr) identified in the BCR gene, lies within a 5.8kb large fragment, spanning exons b1 to b5. The most common M-bcr fusion transcripts are b3a2 and b2a2 or a mixture of both, although some other less common transcripts are also identified, ie b2a3, b3a3 .
Reference range:
PB/BM
Department:
Location:
Sample type and Volume required:
EDTA
Turnaround time:
2 weeks
Special sample instructions:
Samples should reach the laboratory within 24 hours of being taken
Storage and transport:
Room temperature, Samples in EDTA preservative
Contacts:
Cancer Genetics at Guy's Hospital
020 7188 1716
synnovis.seglh-ods@nhs.net
Genetics Department
Guy's Hospital
Great Maze Pond
London SE1 9RT
Please note, the contact details above are for clinicians and laboratory users only. The laboratory is unable to discuss tests and results directly with patients. Patients should contact their own clinician in the event of any queries or concerns.
Guy's Hospital
Great Maze Pond
London SE1 9RT
Please note, the contact details above are for clinicians and laboratory users only. The laboratory is unable to discuss tests and results directly with patients. Patients should contact their own clinician in the event of any queries or concerns.
Laboratory:
Last updated: 07/08/2015
