BRAF Mutations

BRAF gene mutations are found in many different cancers, the highest incidence being found in malignant melanoma, papillary thyroid cancer, colorectal cancer and serous ovarian cancer. Approximately 40-60% of melanomas contain a mutation in the gene that encodes for BRAF. This has led to the development of melanoma therapies that specifically inhibit the mutant BRAF. The presence of the activating V600E BRAF mutation in a tumour indicates poor prognosis in colorectal cancer, and possibly also in other cancer types such as thyroid and lung cancers.
Reference range: 


Sample type and Volume required: 
Paraffin embeded curls/fresh tissue
Turnaround time: 
5 days
Storage and transport: 
Room temp
Molecular Oncology Unit at Guy's
020 7188 1716
Genetics Department
Southwark Wing - 4th Floor
Guy's Hospital
Great Maze Pond
London SE1 9RT

For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 07/08/2015