Hepatitis B Genotyping

In-house sequencing assay that detects mutations in the Hepatitis B virus surface antigen gene and domains A to E of the overalpping DNA polymerase gene. Used to provide genotype and resistance profiles against currently used anti-virals. This test is not performed routinely every week but is batch tested according to demand.
Note: This test is not UKAS accredited.
Clinical details: 
Hepatitis B genotype has been associated with disease progression and treatment outcomes in retrospective studies but is not currently recommended in guiding therapy choices. Resistance patterns are important for individuals who have had previous exposure to antivirals or who appear to be failing treatment.
Reference range: 

Not Applicable

Synonyms or keywords: 
Not Applicable
Sample type and Volume required: 
4-9ml Purple Top EDTA blood (for whole blood or plasma). If insufficient plasma available 2.5 – 5ml Yellow Top Serum Separation Tube (SST) Clotted Blood (for serum) may be used.
Turnaround time: 
Up to 3 weeks
Storage and transport: 
Place labelled sample in a sealed sample bag and send to Central Specimen Reception (CSR). Samples should be sent to CSR promptly as the sensitivity of assays that detect RNA/DNA depend on sample quality/integrity. Please store samples in a refrigerator if there is a delay in sending samples to CSR.
Infection Sciences Department at St Thomas' Hospital
020 7188 8008
St Thomas' Hospital
North Wing - 5th Floor
Westminster Bridge Road
London SE1 7EH
Core opening hours: Monday-Friday 0900-1730

For clinical advice or interpretation of results, please contact the laboratory in the first instance.

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Last updated: 06/10/2023